Hossein A Ghofrani Selected Research

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

2/2011	Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.
1/2007	Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
4/2006	Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
9/2005	Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
12/2003	Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.

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Hossein A Ghofrani Research Topics

Disease

53	Pulmonary Hypertension 09/2021 - 11/2002
35	Pulmonary Arterial Hypertension 01/2021 - 07/2003
30	Hypoxia (Hypoxemia) 01/2022 - 12/2003
7	Familial Primary Pulmonary Hypertension 01/2022 - 09/2008
7	Vascular Remodeling 01/2019 - 04/2011
7	Fibrosis (Cirrhosis) 01/2019 - 12/2008
6	Emphysema 01/2021 - 10/2011
6	Hypertrophy 01/2021 - 11/2008
4	Inflammation (Inflammations) 01/2021 - 05/2010
4	Ventricular Remodeling 01/2021 - 02/2012
4	Chronic Obstructive Pulmonary Disease (COPD) 07/2020 - 06/2015
3	Heart Failure 01/2019 - 03/2018
3	Right Ventricular Hypertrophy 11/2017 - 04/2011
3	Cardiomegaly (Heart Hypertrophy) 06/2011 - 01/2004
3	Lung Injury 11/2009 - 05/2008
3	Edema (Dropsy) 05/2008 - 03/2005
3	Erectile Dysfunction 08/2006 - 06/2004
2	Idiopathic Pulmonary Fibrosis 01/2022 - 10/2010
2	Body Weight (Weight, Body) 01/2021 - 06/2011
2	Connective Tissue Diseases (Connective Tissue Disease) 10/2014 - 11/2005
2	Acidosis 01/2012 - 11/2009
2	Hypercapnia 01/2012 - 11/2009
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2010 - 10/2008
2	Pneumonia (Pneumonitis) 05/2010 - 07/2003
2	Headache (Headaches) 06/2009 - 08/2004
2	Flushing 06/2009 - 11/2005
1	Hypoventilation 09/2021
1	Pulmonary Atelectasis 09/2021
1	Anemia 01/2021
1	Cardiomyopathies (Cardiomyopathy) 01/2021
1	Iron Deficiencies 01/2021
1	COVID-19 01/2021
1	Stroke (Strokes) 01/2021

Drug/Important Bio-Agent (IBA)

11	Sildenafil Citrate (Viagra)FDA Link 06/2015 - 04/2003
10	MonocrotalineIBA 01/2018 - 01/2004
9	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 06/2004
8	Oxygen (Dioxygen)IBA 01/2020 - 12/2003
8	Superoxides (Superoxide)IBA 01/2020 - 12/2003
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2004
7	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2020 - 05/2004
7	treprostinil FDA Link 01/2020 - 01/2006
7	Iloprost (Ventavis)FDA Link 07/2019 - 11/2002
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2014
6	Imatinib Mesylate (Gleevec)FDA Link 01/2013 - 09/2005
5	SmokeIBA 01/2021 - 10/2011
5	Endothelin Receptor AntagonistsIBA 12/2011 - 10/2006
5	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidIBA 02/2011 - 12/2003
4	Tadalafil (Cialis)FDA Link 10/2020 - 10/2004
4	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2018 - 12/2003
4	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 12/2011 - 11/2002
4	Vasoconstrictor AgentsIBA 06/2011 - 07/2005
4	ThromboxanesIBA 02/2011 - 12/2003
4	Phosphodiesterase 5 InhibitorsIBA 10/2006 - 01/2004
3	riociguatIBA 01/2019 - 08/2012
3	4-S-(propionic acid)sulfidocyclophosphamide (PASP)IBA 01/2019 - 09/2018
3	Soluble Guanylyl CyclaseIBA 06/2015 - 03/2009
3	ambrisentan FDA Link 06/2014 - 06/2008
3	Pharmaceutical PreparationsIBA 06/2011 - 08/2004
3	Bosentan (Tracleer)FDA Link 06/2011 - 12/2008
3	Phosphotransferases (Kinase)IBA 04/2011 - 11/2008
3	ProstaglandinsIBA 02/2009 - 07/2003
2	Type 6 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022 - 10/2010
2	Cysteine (L-Cysteine)FDA Link 01/2022 - 08/2017
2	CalciumIBA 01/2022 - 08/2017
2	Vasodilator Agents (Vasodilators)IBA 09/2021 - 06/2015
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 09/2008
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 12/2003
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2021 - 06/2008
2	Semaxinib (SU5416)IBA 10/2020 - 09/2008
2	NADPH Oxidase 2IBA 01/2020 - 02/2014
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2019 - 01/2012
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2019 - 01/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 04/2011
2	P-SelectinIBA 01/2019 - 12/2016
2	Carbon DioxideIBA 10/2017 - 06/2015
2	Endothelins (Endothelin)IBA 10/2014 - 06/2009
2	Messenger RNA (mRNA)IBA 12/2013 - 05/2004
2	TRPC6 Cation ChannelIBA 12/2013 - 05/2009
2	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 01/2012 - 11/2009
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 04/2011 - 11/2008
2	Tyrosine Kinase InhibitorsIBA 12/2010 - 11/2008
2	Arginine (L-Arginine)FDA Link 11/2009 - 03/2009
2	BuffersIBA 05/2008 - 01/2006
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 08/2006 - 10/2004
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2022
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	Growth Factor ReceptorsIBA 01/2021
1	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 01/2021
1	ferric carboxymaltoseIBA 01/2021
1	Transferrin (beta 2 Transferrin)IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2021
1	Ferritins (Ferritin)IBA 01/2021
1	Ion Channels (Ion Channel)IBA 01/2021
1	OsteopontinIBA 01/2021
1	Dextrans (Dextran)FDA Link 01/2021
1	IronIBA 01/2021

Therapy/Procedure

18	Therapeutics 01/2021 - 07/2003
4	Endarterectomy (Thromboendarterectomy) 01/2018 - 12/2008
3	Cardiac Catheters 02/2009 - 12/2006
2	Catheters 01/2020 - 10/2018